Biomedical sciences publications
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Genetic Influences in the Variation in Renal Clearance of Nicotine and Cotinine
In this study of 139 pairs of twins, we have estimated the genetic and environmental contributions to total renal clearance and net secretory/ reabsorptive clearance of nicotine and cotinine.
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Detoxification of Molinate Sulfoxide: Comparison of Spontaneous and Enzmatic Glutathione Conjugation Using Human and Rat Liver Cytosol
This study compared the metabolic capability of rat and human liver cytosol to form a glutathione (GSH)-conjugated metabolite of molinate.
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17 Alpha-Estradiol: a Less-Feminizing Estrogen
A substantial number of studies report that 17β-estradiol (E2; estrogen), a potent endogenous feminizing hormone, is neuroprotective.
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In Vivo Evidence for Alcohol-Induced Neurochemical Changes in Rat Brain Without Protracted Withdrawal, Pronounced Thiamine Deficiency, or Severe Liver Damage
Longitudinal effects of alcohol on brain metabolites measured in basal ganglia with single-voxel MRS were investigated in sibling pairs of wild-type Wistar rats, with one rat per pair exposed to…
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Adamantyl-Substituted Retinoid-Derived Molecules That Interact with the Orphan Nuclear Receptor Small Heterodimer Partner: Effects of Replacing the 1-Adamantyl or Hydroxyl Groupon Inhibition of Cancer Cell Growth, Induction of Cancer Cell Apoptosis, and Inhibition of Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase-2 Activity
Abstract (E)-4-[3-(1-Adamantyl)-4′-hydroxyphenyl]-3-chlorocinnamic acid (3-Cl-AHPC) induces the cell-cycle arrest and apoptosis of leukemia and cancer cells. Studies demonstrated that 3-Cl-AHPC bound to the atypical orphan nuclear receptor small heterodimer partner (SHP).…
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Genetic Association of Daytime Sleepiness and Depressive Symptoms in Elderly Men
The objective of this study was to examine whether daytime sleepiness assessed using the Epworth Sleepiness Scale and depressive symptoms assessed using the Geriatric Depression Scale are genetically related.
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Sleep Deprivation Effects on Circadian Clock Gene Expression in the Cerebral Cortex Parallel Electroencephalographic Differences Among Mouse Strains
Sleep deprivation (SD) results in increased electroencephalographic (EEG) delta power during subsequent non-rapid eye movement sleep (NREMS) and is associated with changes in the expression of circadian clock-related genes in…
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Ventricular Expansion After Alcohol Exposure By Vapor Chamber in Wistar Rats
Here, we tested the hypothesis that wild-type Wistar rats, exposed to vaporized alcohol ensuring higher BALs than typically achieved with voluntary consumption in rodents, would model MRI findings in the…
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Ventricular Expansion in Wild-Type Wistar Rats After Alcohol Exposure By Vapor Chamber
Here, we tested the hypothesis that wild-type Wistar rats, exposed to vaporized alcohol ensuring higher BALs than typically achieved with voluntary consumption in rodents, would model MRI findings in the…
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Hypocretin/Orexin and Nociceptin/Orphanin Fq Coordinately Regulate Analgesia in a Mouse Model of Stress-Induced Analgesia
Stress-induced analgesia (SIA) is a key component of the defensive behavioral “fight-or-flight” response. Although the neural substrates of SIA are incompletely understood, previous studies have implicated the hypocretin/orexin (Hcrt) and…
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Shock Veins in L6 Chondrites and Constraints on the Impact History of the L6 Parent Body
In this study we use hydrodynamic calculations to explore possible impact conditions and sample locations on the L6 parent body for the highly shocked L6 chondrite RC106.
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Telephone-Based Tobacco-Cessation Treatment Re-Enrollment Among Diverse Groups
This study aimed to determine the rates of quitline re-enrollment and to compare the responses of people of varying racial/ethnic identities to invitations utilizing different communication strategies.