Biomedical sciences publications
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Neuroinflammation as a Neurotoxic Mechanism in Alcoholism: Commentaryon “Increased Mcp-1 and Microglia in Various Regions of Human Alcoholic Brain”
Neuropathological studies of chronic alcoholism indicate that loss of neurons is selective to frontal cortex (Courville, 1955, Harper and Kril, 1990) with little evidence for widespread cell loss (Harper, 1998,…
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Identification of a Population of Sleep-Active Cerebral Cortex Neurons
We have identified a population of cells in the cortex that is activated during sleep in three mammalian species. These cortical neurons are a subset of GABAergic interneurons that express…
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Reduced Parasympathetic Activity During Sleep in the Symptomatic Phase of Severe Premenstrual Syndrome
We investigated HRV during sleep, a state that is relatively free of external disruptions, in 9 women with severe PMS and 12 controls.
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Nutritional Stress Affects Mosquito Survival and Vector Competence for West Nile Virus
We evaluated the effect of different sucrose meals following a blood meal containing West Nile virus (WNV) on Culex pipiens pipiens survival, nutritional status, and susceptibility to viral infection and transmission.
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Cortical Processing of Respiratory Occlusion Stimuli in Children with Central Hypoventilation Syndrome
Cortical integration of afferent mechanical stimuli caused by respiratory loading or upper airway occlusion can be tested by measuring respiratory-related evoked potentials (RREPs). We hypothesized that patients with CHS would…
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Sleep Deprivation Effects on Circadian Clock Gene Expression in the Cerebral Cortex Parallel Electroencephalographic Differences Among Mouse Strains
Sleep deprivation (SD) results in increased electroencephalographic (EEG) delta power during subsequent non-rapid eye movement sleep (NREMS) and is associated with changes in the expression of circadian clock-related genes in…
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Callosal Microstructural Degradation Affects Self-And Externally-Directed Visual Conjunction Search in Aging and Alcoholism
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Image-Guided Surgical Navigation in Implant-Based Auricular Reconstruction
In cases where surgical reconstruction is not an option, placement of osseo-integrated implants for an auricular prosthesis can be done in 1 or 2 stages in a relatively short period…
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Nicotinic Acetylcholine Receptor Beta 2 Subunit Gene Implicated in a Systems-Based Candidate Gene Study of Smoking Cessation
We performed a systems-based candidate gene study of 1295 single nucleotide polymorphisms (SNPs) in 58 genes within the neuronal nicotinic receptor and dopamine systems to investigate their role in smoking…
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Perceived Sleep Quality and Sleepiness in South African University Students
Nine hundred and eighty-six undergraduate students completed a questionnaire about their sleep and lifestyle habits over the previous month, and their fatigue-related driving history.
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Long-Term Alcohol Exposure By Vapor Chamber Alters MRS Detectable Metabolites in Rat Striatum
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Hypoxia Signals Autophagy in Tumor Cells Via AMPK Activity, Independent of HIF-1, BNIP3, and BNIP3L
Here we report that oxygen deprivation can activate the autophagic pathway in human cancer cell lines. We observed that hypoxia induced distinct cellular changes characteristic of autophagy such as an…