Biomedical sciences publications
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Effect of Resveratrol on 17 Beta-Estradiol Sulfation By Human Hepatic and Jejunal S9 and Recombinant Sulfotransferase 1E1
Abstract The purpose of this study was to investigate the sulfation of resveratrol (3,5,4′-trihydroxystilbene) and its potential to exhibit drug-drug interactions via sulfation. The possible interaction of resveratrol with 17β-estradiol…
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Frontal Callosal Integrity Predicts Cognitive Interference Compromise in Hiv-Infected Individuals Comorbid for Alcoholism
Diffusion tensor imaging was used to study the combined effects of HIV-infection and alcoholism (ALC) on corpus callosum (CC) integrity in relation to processes of attentional allocation and conflict resolution…
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Volume Reconstruction By Inverse Interpolation: Application to Interleaved MR Motion Correction
We introduce in this work a novel algorithm for volume reconstruction from data acquired on an irregular grid, e.g., from multiple co-registered images.
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Differential Expression of Clock-Related Genes in the Cerebral Cortex of Inbred Mouse Strains in Response to Sleep Deprivation
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Selective 5HT2A and 5HT6 Receptor Antagonists Promote Sleep in Rats
Serotonin (5-HT) has long been implicated in the control of sleep and wakefulness. This study evaluated the hypnotic efficacy of the 5-HT6 antagonist RO4368554 (RO) and the 5-HT2A receptor antagonist MDL100907 (MDL)…
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Callosal Compromise Differentially Affects Conflict Processing and Attentional Allocation in Alcoholism, HIV, and Their Comorbidity
Diffusion tensor imaging was used to study the combined effects of HIV-infection and alcoholism (ALC) on corpus callosum (CC) integrity in relation to processes of attentional allocation and conflict resolution…
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Effects of Saporin-Induced Lesions of Three Arousal Populations on Daily Levels of Sleep and Wake
Here, we directly test this hypothesis by a simultaneous triple lesion of these neurons using three saporin-conjugated neurotoxins.
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Anti-Nociceptive and Anti-Allodynic Effects of a High Affinity NOP Hexapeptide [Ac-RY(3-Cl)YRWR-NH2] (Syn 1020) in Rodents
Syn 1020, a NOP receptor directed peptide, administered systemically has anti-nociceptive activity in both acute and chronic pain models in mice and rats respectively.
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SR 16435 [1-(1-(Bicyclo[3.3.1]nonan-9-yl)piperidin-4-yl)indolin-2-one], a Novel Mixed Nociceptin/Orphanin FQ/μ-Opioid Receptor Partial Agonist: Analgesic and Rewarding Properties in Mice
We identified a novel nociceptin/orphanin FQ (NOP)/μ-opioid receptor agonist, SR 16435 [1-(1-(bicyclo[3.3.1]nonan-9-yl)piperidin-4-yl)indolin-2-one], with high binding affinity and partial agonist activity at both receptors.
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The comprehensive updated regulatory network of Escherichia coli K-12
One hundred and fifty new interactions have been added to our databases as a result of this specific curation effort, in addition to those added as a result of our…
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Software Supported Pattern Development in Intelligence Analysis
This paper describes the GEM pattern language for encoding analysts’ information needs in graphical patterns, and its use in the Link Analysis Workbench (LAW) system to find inexact matches to…
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Issues in Algorithm Characterization for Link Analysis
In this paper, we outline techniques for modeling algorithms that allow a system architecture to reason about their behavior and performance, individually and in combination.