SRI International
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Using Analytics for Improving Implementation Fidelity in a Large Scale Efficacy Trial
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Brain Connectivity Changes over Time in Alcoholism
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Deuterium Protection of Polyunsaturated Fatty Acids against Lipid Peroxidation: A Novel Approach to Mitigating Mitochondrial Neurological Diseases
Oxidative stress is associated with numerous neurological disorders. Mitochondrial malfunction contributes to generation of reactive oxygen species (ROS) in proximity to mitochondrial membranes rich in polyunsaturated fatty acids (PUFAs). ROS initiate PUFA autoxidation, a chain reaction that alters membrane fluidity and promotes toxic reactive carbonyl products (RCP) that damage proteins and DNA. Due to the…
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Implementation of an Intelligent Tutoring System for Online Homework Support at Large Scale
In this paper, we describe an ongoing randomized controlled trial (RCT) to evaluate the efficacy of a web-based tutoring system—the ASSISTments—as support for homework.
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PIDGIN: Privacy-Preserving Interest and Content Sharing in Opportunistic Networks
This paper addresses the research challenges inherent to the exchange of content and interests without compromising the privacy of subscribers, and allowing unauthorised access to untrusted brokers. Specifically, this paper presents an interest and content sharing solution that addresses these security challenges and preserves privacy in opportunistic networks.
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Implementation of an Intelligent Tutoring System for Online Homework Support in an Efficacy Trial
In this paper, we describe an ongoing randomized controlled trial (RCT) to evaluate the efficacy of a web-based tutoring system—the ASSISTments—as support for homework.
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The CHERI Capability Model: Revisiting RISC in an Age of Risk
Motivated by contemporary security challenges, we reevaluate and refine capability-based addressing for the RISC era. We present CHERI, a hybrid capability model that extends the 64-bit MIPS ISA with byte-granularity memory protection.
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Dynamic Metabolic Imaging of Hyperpolarized [2-C-13]Pyruvate Using Spiral Chemical Shift Imaging with Alternating Spectral Band Excitation
This study introduces a sequence for three-dimensional CSI of [2-(13) C]pyruvate using spectrally selective excitation of limited frequency bands containing a subset of metabolites. Dynamic CSI data were acquired alternately from multiple frequency bands in phantoms for sequence testing and in vivo in rat heart.
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A Genome-Scale Metabolic Flux Model of Escherichia coli K-12 Derived from the EcoCyc Database
We present EcoCyc–18.0–GEM, a genome-scale model of the E. coli K–12 MG1655 metabolic network.
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Evidence for the Role of EPHX Gene Variants in Anorexia Nervosa
To identify genetic variants associated with AN, we pursued a series of sequencing and genotyping studies focusing on the coding regions and upstream sequence of 152 candidate genes in a total of 1205 AN cases and 1948 controls.
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In Vivo Diffusion Tensor Imaging Evidence for Reversible White Matter Microstructural Integrity Disruption: Effects of Abstinence in Rat and Man
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Sleep EEG Evidence of Early Brain Recovery with Abstinence in Long-Term Alcoholics