SRI International
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Sleep-Wake Regulation Is Altered in Mice Lacking Trace Amine-Associated Receptor 1
Here, we tested the hypothesis that endogenous TAAR1 tone contributes to the normal regulation of sleep and wakefulness. Abnormal levels of TAs have long been associated with neuropsychiatric disorders; altered TAAR1 regulation of the monoamines may therefore underlie the sleep disturbances that are frequently comorbid with mental illness.
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α4β2* and α7 Nicotinic Receptors Play a Role in L-Dopa-Induced Dyskinesias; Studies Using Parkinsonian Knockout Mice
Since α4a5β2 nAChRs are also predominantly on striatal dopamine terminals, these data suggest that drugs targeting α4β2 nAChRs may reduce L-dopa-induced dyskinesias in late stage Parkinson’s disease.
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Vagal Withdrawal During Hot Flashes Occurring in Undisturbed Sleep
Little is known about the impact of hot flashes on cardiac autonomic regulation, in particular vagal control. Thereby, we assessed the cardiac autonomic profile associated with physiological hot flashes occurring in undisturbed sleep.
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Autonomic Regulation across Phases of the Menstrual Cycle and Sleep Stages in Women with Premenstrual Syndrome and Healthy Controls
To investigate the influence of menstrual cycle phase and the presence of severe premenstrual symptoms on cardiac autonomic control during sleep, we performed heart rate variability (HRV) analysis.
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Imaging Hippocampal Neuronal Activity across Sleep/Wake States in Freely Behaving Mice
We have utilized a combination of methodologies that collectively enable time-lapse imaging of CA1 neuronal calcium dynamics in behaving mice over periods of many weeks.
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Quality Measure Functions for Calibration of Speaker Recognition Systems in Various Duration Conditions
This paper investigates the effect of utterance duration to the calibration of a modern i-vector speaker recognition system with probabilistic linear discriminant analysis (PLDA) modeling.
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Consideration of Species Differences in Developing Novel Molecules as Cognition Enhancers
The issues covered here will aid in task development and utilization across species as well as reinforcing the positive role preclinical research can have in developing procognitive treatments for psychiatric disorders.
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Recent Developments in Voice Biometrics: Robustness and High Accuracy
We highlight SRI’s innovations that resulted from the IARPA Biometrics Exploitation Science & Technology (BEST) and the DARPA Robust Automatic Transcription of Speech (RATS) programs, as well as SRI’s approach for codec degraded speech.
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Reaching Populations Faster in Emergency Management of Disasters – Oral Drugs as Antidotes to Radiation Exposure
Without warning, a major earthquake and subsequent tsunami hit Japan in March 2011. Damage was significant at almost every level, impacting people and the environment. Shortly thereafter, a core meltdown at the Fukushima Daiichi nuclear plant—the largest nuclear event since the Chernobyl disaster in 1986—intensified the situation. Almost immediately concern arose about the many health…
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Invasion biology and the success of social collaboration networks, with application to Wikipedia
We adapt methods from the stochastic theory of invasions for which a key question is whether a propagule will grow to an established population or fail to show how monitoring early participation in a social collaboration network allows prediction of success.
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Miniaturized opto-fluidic system for on-the-flow analyte characterization based on spatial modulation technique
A compact opto-fluidic detection platform for on-the-flow analyte characterization is described.
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A graph lattice approach to maintaining and learning dense collections of subgraphs as image features
This paper shows how large families of complex image features in the form of subgraphs can be built out of simpler ones through construction of a graph lattice–a hierarchy of related subgraphs linked in a lattice.