Biomedical sciences publications
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First Measurement of the BO B2Σ+ Radiative Lifetime by Laser-Induced Fluorescence Via the B2Σ+–X2Σ+ Transition
Observation of the temporal evolution of the fluorescence following laser excitation of boron monoxide molecules to the B 2Σ+ state is used to extract the radiative lifetime and collisional removal rate constant with…
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Longitudinal Analysis of the Electroencephalogram and Sleep Phenotype in the R6/2 Mouse Model of Huntington’s Disease
We conducted a longitudinal characterization of sleep/wake and electroencephalographic activity in the R6/2 mouse model of Huntington’s disease to determine whether analogous electroencephalographic ‘signatures’ could be identified early in disease…
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Curcumin Regulates Colon Cancer by Inhibiting P-Glycoprotein in Cancerous Colon Perfusion Rat Model
In the present study curcumin inhibitory action on p-glycoprotein increased permeability of irinotecan, so in the colon cancer it would be beneficial if curcumin used as add on therapy.
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Comparison of a New Cobinamide-Based Method to a Standard Laboratory Method for Measuring Cyanide in Human Blood
The authors developed and validated a method to quantify cyanide based on the high binding affinity of the vitamin B12 analog, cobinamide, for cyanide and a major spectral change observed…
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The Association between Postload Plasma Glucose Levels and 38-Year Mortality Risk of Coronary Heart Disease: The Prospective NHLBI Twin Study
We aimed to evaluate whether the association between postload plasma glucose levels (ppGlucose) and long-term risk of mortality from coronary heart disease was independent of or attributable to genes and…
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Potential Reporting Bias in fMRI Studies of the Brain
Functional magnetic resonance imaging (fMRI) studies have reported multiple activation foci associated with a variety of conditions, stimuli or tasks.
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Differential Improvement in Neurocognition with Greater Antiretroviral Cns Penetration Effectiveness in Alcoholism-HIV Infection Comorbidity
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Parathyroid Hormone (PTH) and PTH-Related Peptide Domains Contributing to Activation of Different PTH Receptor-Mediated Signaling Pathways
In the present investigation, a collection of PTH(1-34) and PTHrP(1-34) peptide analogs were evaluated in orthogonal human PTH1R (hPTH1R) functional assays capturing Gs- and Gq-signaling, β-arrestin recruitment, ERK1/2 phosphorylation, and receptor…
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Acute Ethanol Reduces Reversal Cost in Discrimination Learning by Reducing Perseverance in Adolescent Rhesus Macaques
The cognitive impact of acute alcohol exposure includes deficits in discrimination and reversal learning, but traditional experimental approaches make it difficult to distinguish the effect of alcohol on discrimination learning…
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Cardiac Autonomic Activity During Sleep in Recently Sober Alcoholics
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Longitudinal Changes in Sleep EEG and Brain Structure in Adolescence
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Wernicke-Korsakoff Syndrome: A Nutritional Alcohol-Related Brain Disorder