Biomedical sciences publications
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Sleep and Women’s Health: Sex- And Age-Specific Contributors to Alcohol Use Disorders
As part of the 2018 Research Conference on Sleep and the Health of Women at the National Institutes of Health, three presentations focused on the intersection between alcohol and sleep…
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In Vivo Activity of Amodiaquine against Ebola Virus Infection
We investigated the potential anti-EBOV effect of amodiaquine in a well-characterized nonhuman primate model of EVD.
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Engineered Ovarian Cancer Cell Lines for Validation of CAR T Cell Function
A set of genetically engineered isogenic cell lines is developed to express either folate receptor alpha or mesothelin, and a control cell line negative for both antigens.
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REM Sleep-Active MCH Neurons Are Involved in Forgetting Hippocampus-Dependent Memories
Melanin concentrating hormone-producing neurons (MCH neurons) in the hypothalamus actively contribute to forgetting in rapid eye movement (REM) sleep.
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Resources to discover and use short linear motifs in viral proteins
We survey viral uses of SLiMs to mimic host proteins, and information resources available for motif discovery.
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Automatic Artifact Detection in Impedance Cardiogram Using Pulse Similarity Index
We proposed a new algorithm for the automatic detection and exclusion of corrupted ICG cardiac cycles by defining a pulse similarity index that quantifies the level of pulse corruption and…
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Trace Amine-Associated Receptor 1 Agonism Promotes Wakefulness Without Impairment of Cognition in Cynomolgus Macaques
We investigated the effects of TAAR1 agonism in Cynomolgus macaques, a diurnal species that exhibits consolidated night-time sleep, and evaluated the effects of TAAR1 agonists on cognition using a working…
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Wearable Sleep Technology in Clinical and Research Settings
The current state-of-the-art review aims to highlight use, validation and utility of consumer wearable sleep-trackers in clinical practice and research.
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Increased stress associated with head-out plethysmography testing can exacerbate respiratory effects and lead to mortality in rats
The generalized stress inherent to head-out plethysmography testing exacerbated the respiratory effects of DSM421 and was possibly compounded by DSM421’s cardiovascular effects, thus artifactually resulting in moribundity and mortality in…
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Excitation of Cortical nNOS/NK1R Neurons by Hypocretin 1 Is Independent of Sleep Homeostasis
We have proposed that cortical nNOS/NK1R interneurons have a role in sleep homeostasis.
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Neurobiological and Immunogenetic Aspects of Narcolepsy: Implications for Pharmacotherapy
Although only a few drugs have received regulatory approval for narcolepsy to date, treatment involves diverse medications that affect multiple biochemical targets and neural circuits.
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Reducing bedtime physiological arousal levels using immersive audio-visual respiratory bio-feedback: a pilot study in women with insomnia symptoms
The current study evaluated the effect of a novel, acute behavioral experimental manipulation in reducing bedtime physiological hyperarousal in women with insomnia symptoms.