Biomedical sciences publications
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Fast and Ultrafast Kelvin Wave Modulations of the Equatorial Evening F Region Vertical Drift and Spread F Development
In this paper, we investigate the role of eastward and upward propagating fast and ultrafast Kelvin waves in the day-to-day variability of equatorial evening prereversal vertical drift and post sunset…
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The alpha7 Nicotinic Receptor Agonist ABT-107 Protects against Nigrostriatal Damage in Rats with Unilateral 6-Hydroxydopamine Lesions
The objective of this study was twofold: first, to test the protective potential of ABT-107, an agonist with high selectivity for α7 nAChRs; and second, to investigate its cellular mechanism…
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Characterization, HPLC Method Development and Impurity Identification for 3,4,3-Li(1,2-HOPO), a Potent Actinide Chelator for Radionuclide Decorporation
Derivatization of the target ligand in situ with Fe(III) chloride provided a single homogeneous iron-complex that can readily be detected and analyzed by HPLC.
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Cytotoxicity of Human Endogenous Retrovirus K-Specific T Cells toward Autologous Ovarian Cancer Cells
Endogenous retroviral gene products in ovarian cancer may represent a potentially valuable new pool of tumor-associated antigens for targeting of therapeutic vaccines to ovarian cancer.
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Measuring and Statistically Testing the Size of the Effect of a Chemical Compound on a Continuous in-Vitro Pharmacological Response through a New Statistical Model of Response Detection Limit
We used a linearized version of this equation to define a measure of pharmacological effect size, and use this measure to rank the investigated compounds in order of their overall…
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Singlet Molecular Oxygen Formation by O-Atom Recombination on Fused-Quartz Surfaces
Experimental results demonstrate O2(aΔ1g) (υ=0) formation by catalytic O-atom surface recombination in a room-temperature fused-quartz flow-tube reactor.
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BU08073 a Buprenorphine Analog with Partial Agonist Activity at mu Receptors in vitro but Long-Lasting Opioid Antagonist Activity in vivo in Mice
Structure activity studies were conducted to design buprenorphine analogues with high affinity at each of these receptors and to characterize them in in vitro and in vivo assays.
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Quantitative Susceptibility Mapping by Inversion of a Perturbation Field Model: Correlation with Brain Iron in Normal Aging
We present a method for quantifying susceptibility by inversion of a perturbation model, or “QSIP.” The perturbation model relates phase to susceptibility using a kernel calculated in the spatial domain,…
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Variation in the Human Immune System Is Largely Driven by Non-Heritable Influences
To assess the relative contribution of heritable versus non-heritable factors, we have performed a systems-level analysis of 210 healthy twins between 8 and 82 years of age.
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Tenofovir Disoproxil Fumarate: Toxicity, Toxicokinetics, and Toxicogenomics Analysis After 13 Weeks of Oral Administration in Mice
The goals of this study were to evaluate the molecular mechanism of TDF-induced toxicity in mice by correlating transcriptional changes with plasma drug levels and traditional toxicology end points.
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Overlapping and Distinct Molecular Determinants Dictating the Antiviral Activities of Trim56 against Flaviviruses and Coronavirus
We show that TRIM56 poses a barrier to infections by yellow fever virus (YFV), dengue virus serotype 2 (DENV2), and human coronavirus virus (HCoV) OC43 but not encephalomyocarditis virus (EMCV).
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Prophylactic treatment with a novel bioadhesive gel formulation containing aciclovir and tenofovir protects from HSV-2 infection
Over-the-counter access to an inexpensive, effective topical microbicide could reduce the transmission of HIV and would increase women’s control over their health and eliminate the need to obtain their partners’…