Biomedical sciences publications
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Evidence for the Role of EPHX Gene Variants in Anorexia Nervosa
To identify genetic variants associated with AN, we pursued a series of sequencing and genotyping studies focusing on the coding regions and upstream sequence of 152 candidate genes in a…
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Regional Manifold Learning for Disease Classification
We use the regional manifolds as low-dimensional descriptors of high-dimensional morphological image features, which are then fed into a classifier to identify regions affected by disease.
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Effect of Bitopertin, a Glycine Reuptake Inhibitor, on Negative Symptoms of Schizophrenia: A Randomized, Double-Blind, Proof-of-Concept Study
Our objective is to determine the efficacy and safety of bitopertin (RG1678), a glycine reuptake inhibitor, in patients with schizophrenia and predominant negative symptoms who were stable while taking an…
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Evidence of Recovery in Cortico-Cardiac Activity During Sleep in Recently Detoxified Alcoholics
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Sleep EEG Evidence of Early Brain Recovery with Abstinence in Long-Term Alcoholics
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Time to Smoke First Morning Cigarette and Lung Cancer in a Case-Control Study
We evaluated whether time to first cigarette after waking, a single-item measure of nicotine dependency, could improve stratification of lung cancer risk beyond standard smoking metrics.
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Synchrony of Anterior Cingulate Cortex and Insular-Striatal Activation Predicts Ambiguity Aversion in Individuals with Low Impulsivity
To test how dACC functional network connectivity would be modulated by uncertainty and differ between individuals, 24 healthy participants underwent functional MRI in 3 sequential runs: 1 resting-state and 2…
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Uncovering Cryptic Glycan Markers in Multiple Sclerosis (MS) and Experimental Autoimmune Encephalomyelitis (Eae)
We observed epitope-spreading of autoantibody responses to a variety of antigenic structures in the cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS) and in the serum of mice with…
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Characterization of High Frequency Neuronal Oscillations During a Sustained Attention Task in Cynomolgus Macaques Following NMDA Receptor Antagonism
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Global Ethics and Virtual Worlds: Ensuring Functional Integrity in Transnational Research Studies
This paper examines a number of issues in this research context, with particular stress on the challenges posed by transnational experimental projects in virtual worlds and social networks.
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Optogenetic Manipulation of Activity and Temporally Controlled Cell-Specific Ablation Reveal a Role for MCH Neurons in Sleep/Wake Regulation
To determine the physiological role of MCH neurons, newly developed transgenic mouse strains that enable manipulation of the activity and fate of MCH neurons in vivo were generated using the…
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Dissociation of Preparatory Attention and Response Monitoring Maturation During Adolescence
The objective was to assess development of EEG markers of these strategies and their role in both preparatory attention (contingent negative variation, CNV) and response monitoring (Error Related Negativity, ERN,…