Biomedical sciences publications
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Brain Connectivity Changes over Time in Alcoholism
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Deuterium Protection of Polyunsaturated Fatty Acids against Lipid Peroxidation: A Novel Approach to Mitigating Mitochondrial Neurological Diseases
Oxidative stress is associated with numerous neurological disorders. Mitochondrial malfunction contributes to generation of reactive oxygen species (ROS) in proximity to mitochondrial membranes rich in polyunsaturated fatty acids (PUFAs). ROS…
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Heterogeneity of Alcohol Effects on Nodes of Frontocerebellar and Limbic Circuitry: Evidence from the US-France Collaborative Study
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Sample Collection in Clinical Proteomics – Proteolytic Activity Profile of Serum and Plasma
We utilized the platform to ascertain the impact of three commonly used anticoagulants (EDTA, heparin, and citrate) on the proteolytic activity profile of plasma and serum collected from a healthy…
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Permeability Enhancing Lipid-Based Co-Solvent and SEDDS Formulations of SQ641, an Antimycobacterial Agent
The objective of this study was to develop an oral preclinical liquid formulation of SQ641 and to determine the permeability across rat intestinal tissue by Ussing chamber.
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In Vivo Diffusion Tensor Imaging Evidence for Reversible White Matter Microstructural Integrity Disruption: Effects of Abstinence in Rat and Man
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Dissociation of Preparatory Attention and Response Monitoring Maturation During Adolescence
The objective was to assess development of EEG markers of these strategies and their role in both preparatory attention (contingent negative variation, CNV) and response monitoring (Error Related Negativity, ERN,…
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The 24-H Progression of Menstrual Pain in Women with Primary Dysmenorrhea When Given Diclofenac Potassium: A Randomized, Double-Blinded, Placebo-Controlled Crossover Study
We aimed to investigate the efficacy of the daily recommended dose of diclofenac potassium in treating severe menstrual pain in women with severe primary dysmenorrhea.
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Nicotine Dependence as a Moderator of Genetic Influences on Smoking Cessation Treatment Outcome
In this secondary analysis of clinical trial data, we examined nicotine dependence severity as a moderator of the effects of 1198 single nucleotide polymorphisms (SNPs) in 53 biologically-relevant gene regions…
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Design of a Peptide Inhibitor of Tyrosine Kinase 2
The development of antisense peptide inhibitors is a relatively unexplored area of research, and here we investigate inhibitory peptides specific for the Janus-associated kinase (JAK) family member, tyrosine kinase 2 (TYK2).
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GABAB Agonism Promotes Sleep and Reduces Cataplexy in Murine Narcolepsy
We evaluated the effects of chronic administration of GHB and the GABA B agonist R -baclofen ( R -BAC) on arousal state and cataplexy in two models of narcolepsy: orexin/ataxin-3…
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The Adaptor Protein SAP Regulates Type II NKT-Cell Development, Cytokine Production, and Cytotoxicity against Lymphoma
Here, using a type II NKT-cell TCR transgenic mouse model, we demonstrated that CD1d-expressing hematopoietic cells, but not thymic epithelial cells, meditate efficient selection of type II NKT cells.