Biomedical sciences publications
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Detection of Inflammatory Arthritis By Using Hyperpolarized 13 C-Pyruvate with Mr Imaging and Spectroscopy
The data presented herein suggest that the presence of inflammation may be detected at 13C-MR spectroscopy as the increased conversion of hyperpolarized 13C-pyruvate into 13C-lactate.
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Genetic Variability of Smoking Persistence in African Americans
We undertook an association analysis by using a genotyping array that includes 2,100 genes to analyze smoking persistence in unrelated African American participants from the Atherosclerosis Risk in Communities study.
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Effect of Fenoterol Stereochemistry on the β2 Adrenergic Receptor System: Ligand-Directed Chiral Recognition
The β2 adrenergic receptor (β2-AR) is a model system for studying the ligand recognition process in G protein-coupled receptors. Fenoterol (FEN) is a β2-AR selective agonist that has two centers of…
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Nicotinic Receptor Agonists Decrease L-Dopa-Induced Dyskinesias Most Effectively in Partially Lesioned Parkinsonian Rats
To further understand how nicotine mediates its antidyskinetic action, we investigated the effect of nicotinic receptor (nAChR) agonists in unilateral 6-OHDA-lesioned rats with varying striatal damage.
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Disruption of Emotion and Conflict Processing in HIV Infection with and Without Alcoholism Comorbidity
We investigated whether patients with alcoholism, HIV-1 infection, or both diseases have greater difficulty than healthy controls in resolving conflict from emotional words with different valences.
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Application of Double Spin Echo Spiral Chemical Shift Imaging to Rapid Metabolic Mapping of Hyperpolarized [1 – 13C]-Pyruvate
This work extends the spCSI sequence by incorporating double spin-echo radiofrequency (RF) pulses to eliminate the need for phase correction and obtain high quality spectra in magnitude mode.
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Systems Level in Silico Pathway Analysis Predicts Metabolites That Are Potential Antimicrobial Targets
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Identification of Antimicrobial Activity Among FDA-Approved Drugs for Combating Mycobacterium Abscessus and Mycobacterium Chelonae
The purpose of this work is to identify new candidate drugs for treating non-tuberculous mycobacteria (NTM) by testing FDA-approved drugs for antimicrobial activity.
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A Platform for the Detection of Trypanosomes Via Selective Small Molecule Recognition
Trypanothione (TSH2), a metabolite unique to trypanosomal parasites, was evaluated as a potential biomarker for trypanosomal infection using fluorescence as the means of detection.
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Associations of Cyp2A6 Genotype with Smoking Behaviors in Southern China
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Disruption of Functional Connectivity of the Default-Mode Network in Alcoholism
We examined DMN functional connectivity using functional magnetic resonance imaging (fMRI) data and graph theory analysis.
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Sensitivity to Secondhand Smoke Exposure Predicts Smoking Susceptibility in 8-13-Year-Old Never Smokers
We assessed the sensitivity to SHSe using reactions commonly used for the assessment of sensitivity to the first-smoked cigarette, and investigated the factor structure of these reactions for the purpose…