Biomedical sciences publications
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Vaccination of Rabbits with an Alkylated Toxoid Rapidly Elicits Potent Neutralizing Antibodies Against Botulinum Neurotoxin Serotype B
New Zealand White (NZW) rabbits were immunized with several different nontoxic botulinum neurotoxin serotype B (BoNT/B) preparations in an effort to optimize the production of a rapid and highly potent,…
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Advanced Vehicle Tracking in Persistent Aerial Surveillance Video
This paper presents a relational graph based approach to track thousands of vehicles from persistent wide area airborne surveillance (WAAS) videos.
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LC/MS Characterization of Impurities and Degradation Products of a Potent Antitumor Peptidic Dimer, CU201
An HPLC method was developed, as part of a study supported by the National Cancer Institute's (NCI's) Rapid Access to Interventional Development (RAID) program, to assess the purity and stability…
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Quantitative Fiber Tracking of Lateral and Interhemispheric White Matter Systems in Normal Aging: Relations to Timed Performance
Using our quantitative fiber tracking approach, we assessed fiber tract integrity of samples of major white matter cortical, subcortical, interhemispheric, and cerebellar systems (11 bilateral and 2 callosal) on DTI…
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Global Reemergence of Tuberculosis: Are Host Defense Peptides an Option to Ameliorate Disease Burden?
Intermittent drug therapy due to noncompliance or poor delivery of therapy promotes the emergence of bacterial strains showing resistance to multiple drugs and the rise of extremely drug-resistant strains.
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Orally Bioavailable Anti-HBV Dinucleotide Acyloxyalkyl Prodrugs
The acyloxyalkyl derivatives of a model anti-HBV dinucleotide were synthesized and evaluated as orally bioavailable prodrugs. Our studies have led to the identification of the first orally bioavailable dinucleotide prodrugs…
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Callosal Degradation in HIV-1 Infection Predicts Hierarchical Perception: a DTI Study
We tested whether HIV-related callosal white matter degradation contributes to disruption of selective lateralized visuospatial and attention processes.
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Design of Short Linear Peptides That Show Hydrogen Bonding Constraints in Water
Using a combination of an aromatic amino acid, a homoserine side chain, and a d-amino acid, a series of linear tetrapeptides were designed that adopt an “Hse turn” in water.
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Pharmacokinetics and Metabolism of (R,R)-Methoxyfenoterol in Rat
(R,R)-fenoterol (Fen), a beta(2)-adrenoceptor agonist, is under clinical investigation in the treatment of congestive heart disease.
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A Partially Linear Tree-Based Regression Model for Multivariate Outcomes
We propose a multilocus association test for the study of multivariate traits. The test is derived from a partially linear tree-based regression model for multiple outcomes.
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Increase in Tissue Inhibitor of Metalloproteinase-2 (TIMP-2) Levels and Inhibition of MMP-2 Activity in a Metastatic Breast Cancer Cell Line by an Anti-Invasive Small Molecule SR13179
We report that a novel small molecule synthetic flavanoid SR13179, which inhibits the invasion of a highly metastatic human breast cancer cell line MCF-10CA1a through Matrigel, significantly increases protein and…
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Daytime Sleepiness, Psychomotor Performance, Waking Eeg Spectra and Evoked Potentials in Women with Severe Premenstrual Syndrome
We assessed daytime sleepiness using objective and subjective measures in women with severe premenstrual syndrome (PMS) compared with women without significant premenstrual symptoms.