Publications
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Biological Impact of Low Dose-Rate Simulated Solar Particle Event Radiation in Vivo
C57Bl6-lacZ animals were exposed to a range of low dose-rate simulated solar particle event (sSPE) radiation at the NASA-sponsored Research Laboratory (NSRL) at Brookhaven National Laboratory (BNL).
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Efficient Variable Elimination for Semi-Structured Simple Temporal Networks with Continuous Domains
We show that for an Simple Temporal Network, messages can be represented compactly as sub-STNs. We then present an efficient message-passing scheme for computing the minimal constraints of an STN.
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Preclinical Pharmacokinetic, Toxicological and Biomarker Evaluation of SR16157, a Novel Dual-Acting Steroid Sulfatase Inhibitor and Selective Estrogen Receptor Modulator
SR16157 is a novel dual-acting inhibitor of estrogen action that irreversibly inhibits the estrogen biosynthetic enzyme steroid sulfatase and releases the selective estrogen receptor modulator SR16137, which blocks the estrogen…
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Alpha 6 Beta 2*And Alpha 4 Beta 2*Nicotinic Receptors Both Regulate Dopamine Signaling with Increased Nigrostriatal Damage: Relevance to Parkinson’s Disease
We investigated the effect of varying nigrostriatal damage on α6β2* and α4β2* receptor-modulated dopamine signaling using cyclic voltammetry.
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Nonprofits and the Valley of Death in Drug Discovery
The research and development (R&D) process that ultimately leads to effective drugs is exceedingly difficult, and often the public does not understand the drug discovery pipeline.
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Resequencing of Nicotinic Acetylcholine Receptor Genes and Association of Common and Rare Variants with the Fagerstrom Test for Nicotine Dependence
We investigated the contribution of common SNPs and rare single-nucleotide variants in nAChR genes to Fagerström test for nicotine dependence scores in treatment-seeking smokers.
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Alpha-Synuclein Suppression By Targeted Small Interfering RNA in the Primate Substantia Nigra
The protein α-synuclein is involved in the pathogenesis of Parkinson's disease and other neurodegenerative disorders.
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The CALO meeting assistant system
This paper presents the CALO-MA architecture and its speech recognition and understanding components.
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Optically-pumped lasing of semipolar InGaN/GaN(1122) heterostructures
Results for long-wavelength emitters are presented for growth of semi-polar InGaN/AlGaN/GaN heterostructures on GaN(1122)/m-sapphire templates by metalorganic chemical vapor deposition (MOCVD).
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The “3D Wiki”: blending virtual worlds and web architecture for remote collaboration
In this paper we describe the technology behind our 3D Wiki, a system meant to address this problem.
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One experience collecting sensitive mobile data
We report on our efforts to collect behavioral data based on activities recorded by phones.
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Hybrid X-Ray/Optical Luminescence Imaging: Characterization of Experimental Conditions
This study examines practical aspects of this new modality including phosphor concentration, light emission linearity, detector damage, and spectral emission characteristics.