Publications
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Orally Bioavailable Anti-HBV Dinucleotide Acyloxyalkyl Prodrugs
The acyloxyalkyl derivatives of a model anti-HBV dinucleotide were synthesized and evaluated as orally bioavailable prodrugs. Our studies have led to the identification of the first orally bioavailable dinucleotide prodrugs…
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Quantitative Fiber Tracking of Lateral and Interhemispheric White Matter Systems in Normal Aging: Relations to Timed Performance
Using our quantitative fiber tracking approach, we assessed fiber tract integrity of samples of major white matter cortical, subcortical, interhemispheric, and cerebellar systems (11 bilateral and 2 callosal) on DTI…
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Scaffolding knowledge communities in the classroom: New opportunities in the Web 2.0 era
This chapter reports two studies that used a wiki to deliver a new curriculum model that blends scripted inquiry activities with collaborative knowledge construction in secondary school biology.
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Discounted Deterministic Markov Decision Processes and Discounted All-Pairs Shortest Paths
We present algorithms for finding optimal strategies for discounted, infinite-horizon, Determinsitc Markov Decision Processes (DMDPs).
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Nicotinic Receptor-Mediated Reduction in L-DOPA-Induced Dyskinesias May Occur Via Desensitization
The present experiments were performed to understand the mechanisms whereby nicotine reduces l-DOPA-induced AIMs. We used a well established model of dyskinesias, l-DOPA-treated unilateral 6-hydroxydopamine-lesioned rats.
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Comparing the contributions of context and prosody in text-independent dialog act recognition
We propose a framework for employing both speech/non-speech-based (“contextual”) features and prosodic features, and apply it to DA segmentation and classification in multiparty meetings.
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Dynamics of North American Sector Ionospheric and Thermospheric Response During the November 2004 Superstorm
We present a study of ionospheric and thermospheric response during a November 9–10, 2004 major geomagnetic storm event (DsT ∼−300 nT).
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A Partially Linear Tree-Based Regression Model for Multivariate Outcomes
We propose a multilocus association test for the study of multivariate traits. The test is derived from a partially linear tree-based regression model for multiple outcomes.
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Increase in Tissue Inhibitor of Metalloproteinase-2 (TIMP-2) Levels and Inhibition of MMP-2 Activity in a Metastatic Breast Cancer Cell Line by an Anti-Invasive Small Molecule SR13179
We report that a novel small molecule synthetic flavanoid SR13179, which inhibits the invasion of a highly metastatic human breast cancer cell line MCF-10CA1a through Matrigel, significantly increases protein and…
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Spectacular Low- and Mid-Latitude Electrical Fields and Neutral Winds During a Superstorm
In November 2004, a major magnetic storm occurred, a lengthy portion of which was recorded by the Upper Atmospheric Radar Chain.
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The Economic Impact of Engineering Research Centers: Preliminary Results of a Pilot Study
This article describes the results of a pilot study that tested the feasibility of estimating quantitatively the regional and economic impacts of NSF-supported Engineering Research centers.
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An Analysis of Student Practices in Asynchronous Computer Conferencing Courses
The current study examined the online habits and “survival strategies” of 57 students enrolled in graduate-level distance education courses.