SRI International
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Identification and optimization of PDE10A inhibitors using fragment-based screening by nanocalorimetry and X-ray crystallography
Here we use enthalpy arrays, which are arrays of nanocalorimeters, to perform an enzyme activity-based fragment screen for competitive inhibitors of phosphodiesterase 10A (PDE10A).
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Community Colleges Provide Invaluable Stepping Stone for Autistic Youth
Community colleges may provide a smoother transition to the academic and social challenges that can arise in a university setting. These institutions may be particularly appealing for students with autism spectrum disorders (ASDs) to pursue postsecondary education while still remaining at home, where they have the continuity of family support and a consistent environment. To…
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The Influence of Family Socioeconomic Status on the Post–High School Outcomes of Youth With Disabilities
Results show that SES had a statistically significant but relatively small effect on outcomes, to a sizable extent the effect of SES was mediated by other factors…
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Maternal Nutrition at Conception Modulates DNA Methylation of Human Metastable Epialleles
We show that significant seasonal variations in methyl-donor nutrient intake of mothers around the time of conception influence 13 relevant plasma biomarkers. Our results demonstrate that maternal nutritional status during early pregnancy causes persistent and systemic epigenetic changes at human metastable epialleles.
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Auroral Ionospheric F Region Density Cavity Formation and Evolution: Mica Campaign Results
Auroral ionospheric F region density depletions observed by PFISR (Poker Flat Incoherent Scatter Radar) during the MICA (Magnetosphere-Ionosphere Coupling in the Alfvén Resonator) sounding rocket campaign are critically examined alongside complementary numerical simulations.
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Experimental Demonstration of a Broadband All-Dielectric Metamaterial Perfect Reflector
Here we present the demonstration of a single-negative all-dielectric metamaterial that possesses peak reflectance over 99% and an average reflectance over 98% across a 200 nm wide bandwidth in the short-wavelength infrared region.
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No Association between Germline Variation in Catechol-O-Methyltransferase and Colorectal Cancer Survival in Postmenopausal Women
Because catechol-O-methyltransferase (COMT; 22q11.21) activity is an important component of estrogen-mediated carcinogenesis, we hypothesized that germline variation in COMT may be associated with CRC survival.
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Sudemycin E Influences Alternative Splicing and Changes Chromatin Modifications
To determine the effect on gene expression, we performed genome-wide array analysis. Sudemycin E first causes a rapid change in alternative pre-messenger RNA splicing, which is later followed by changes in overall gene expression and arrest in the G2 phase of the cell cycle.
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Advice for Mathematical Argumentation
“Telling” can be an effective tool in helping students engage in intellectually demanding argumentation and productive behavior.
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Generalized Effective-Medium Theory for Metamaterials
We present an effective-medium model for calculating the frequency-dependent effective permittivity ε(ω) and permeability μ(ω) of metamaterial composites containing spherical particles with arbitrary permittivity and permeability.
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ISOMER: Informative Segment Observations for Multimedia Event Recounting
This paper describes a system for multimedia event detection and recounting. The goal is to detect a high level event class in unconstrained web videos and generate event oriented summarization for display to users.
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Multi-Modal Image Retrieval for Complex Queries Using Small Codes
We propose a unified framework for image retrieval capable of handling complex and descriptive queries of multiple modalities in a scalable manner.