Author: Thomas Kilduff
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Acute Optogenetic Silencing of Orexin/Hypocretin Neurons Induces Slow-Wave Sleep in Mice
Our results demonstrate that acute inhibition of orexin neurons results in time-of-day-dependent induction of SWS and in reduced firing rate of neurons in an efferent projection site thought to be involved in arousal state regulation.
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Activation of Cortical Interneurons During Sleep: An Anatomical Link to Homeostatic Sleep Regulation?
We propose that cortical nNOS neurons are positioned to influence neuronal activity across widespread brain areas.
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Sleep-Active Cells in the Cerebral Cortex and Their Role in Slow-Wave Activity
We recently identified neurons in the cerebral cortex that become activated during sleep episodes with high slow-wave activity (SWA).
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Sleep-Active Neuronal Nitric Oxide Synthase-Positive Cells of the Cerebral Cortex: a Local Regulator of Sleep?
We review the possible functions of neuronal nitric oxide synthase in regulating neuronal activity, synaptic plasticity and cerebral blood flow within the context of local sleep regulation in the cerebral cortex.
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Selective 5HT2A and 5HT6 Receptor Antagonists Promote Sleep in Rats
Serotonin (5-HT) has long been implicated in the control of sleep and wakefulness. This study evaluated the hypnotic efficacy of the 5-HT6 antagonist RO4368554 (RO) and the 5-HT2A receptor antagonist MDL100907 (MDL) relative to zolpidem.