Biomedical sciences publications
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Poor Autonomic Nervous System Functioning During Sleep in Recently Detoxified Alcohol-Dependent Men and Women
We investigated nighttime ANS functioning, and the relation between ANS activity and severity of alcohol dependence in chronic alcoholism.
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Conditional Ablation of Orexin/Hypocretin Neurons: A New Mouse Model for the Study of Narcolepsy and Orexin System Function
The sleep disorder narcolepsy results from loss of hypothalamic orexin/hypocretin neurons. Although narcolepsy onset is usually postpubertal, current mouse models involve loss of either orexin peptides or orexin neurons from…
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Synchrony of Anterior Cingulate Cortex and Insular-Striatal Activation Predicts Ambiguity Aversion in Individuals with Low Impulsivity
To test how dACC functional network connectivity would be modulated by uncertainty and differ between individuals, 24 healthy participants underwent functional MRI in 3 sequential runs: 1 resting-state and 2…
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Uncovering Cryptic Glycan Markers in Multiple Sclerosis (MS) and Experimental Autoimmune Encephalomyelitis (Eae)
We observed epitope-spreading of autoantibody responses to a variety of antigenic structures in the cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS) and in the serum of mice with…
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Characterization of High Frequency Neuronal Oscillations During a Sustained Attention Task in Cynomolgus Macaques Following NMDA Receptor Antagonism
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Global Ethics and Virtual Worlds: Ensuring Functional Integrity in Transnational Research Studies
This paper examines a number of issues in this research context, with particular stress on the challenges posed by transnational experimental projects in virtual worlds and social networks.
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Optogenetic Manipulation of Activity and Temporally Controlled Cell-Specific Ablation Reveal a Role for MCH Neurons in Sleep/Wake Regulation
To determine the physiological role of MCH neurons, newly developed transgenic mouse strains that enable manipulation of the activity and fate of MCH neurons in vivo were generated using the…
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No Association between Germline Variation in Catechol-O-Methyltransferase and Colorectal Cancer Survival in Postmenopausal Women
Because catechol-O-methyltransferase (COMT; 22q11.21) activity is an important component of estrogen-mediated carcinogenesis, we hypothesized that germline variation in COMT may be associated with CRC survival.
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Designing Bifunctional NOP Receptor-Mu-Opioid Receptor Ligands from NOP-Receptor Selective Scaffolds. Part II
We describe a continuing structure–activity relationship (SAR) study of the NOP-selective piperidin-4-yl-1,3-dihydroindol-2-one scaffold, to obtain bifunctional activity at MOP, and a suitable ratio of NOP/MOP agonist activity that produces a…
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Sudemycin E Influences Alternative Splicing and Changes Chromatin Modifications
To determine the effect on gene expression, we performed genome-wide array analysis. Sudemycin E first causes a rapid change in alternative pre-messenger RNA splicing, which is later followed by changes…
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Maternal Nutrition at Conception Modulates DNA Methylation of Human Metastable Epialleles
We show that significant seasonal variations in methyl-donor nutrient intake of mothers around the time of conception influence 13 relevant plasma biomarkers. Our results demonstrate that maternal nutritional status during…
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ABT-089 and ABT-894 reduce levodopa-induced dyskinesias in a monkey model of Parkinson’s disease
Here, we examined the effect of two β2 nAChR agonists, ABT-089 and ABT-894, that previously were approved for phase 2 clinical trials for other indications.