Biomedical sciences publications
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Longitudinal Changes in Sleep EEG and Brain Structure in Adolescence
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Wernicke-Korsakoff Syndrome: A Nutritional Alcohol-Related Brain Disorder
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Antileishmanial Activity of Natural Product-Like Naphthoquinones
The antileishmanial activity of compounds inspired by naphthoquinone secondary metabolites from Bignoniaceae is presented.
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Structure and Function of Parkin E3 Ubiquitin Ligase Reveals Aspects of RING and HECT Ligases
Here we present the 1.58 Å structure of Parkin-R0RBR, revealing the fold architecture for the four RING domains, and several unpredicted interfaces.
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Interleukin-6 Gene Polymorphism (−174 G/C) is Associated with Toxoplasmic Retinochoroiditis
This study suggests that the genotypes related with a lower production of IL-6 may be associated with the occurrence of TR.
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Implicit Alcohol-Related Associations Affect Decision-Making in Abstinent Alcoholics
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Intrinsic Functional Connectivity in Alcoholism: Test-Retest Stability and Normalization with Sobriety
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Importance of the Nicotinic Acetylcholine Receptor System in the Prefrontal Cortex
In this work we review, in light of the latest findings, how nicotinic agonists may be acting in the PFC to influence cognitive function.
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In Vivo Measurement of Aldehyde Dehydrogenase-2 Activity in Rat Liver Ethanol Model Using Dynamic MRSI of Hyperpolarized [1-(13) C] Pyruvate
In this work, we show that dynamic MRSI of hyperpolarized pyruvate and its conversion to [1-13C]lactate can provide an indirect in vivo measurement of ALDH2 activity via the concentration of NADH.
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Polysomnographic Validation of a Wireless Dry Headband Technology for Sleep Monitoring in Healthy Young Adults
The present study aimed to explore the validity and reliability of a wireless dry headband technology for sleep monitoring (WS), through a comparison with concurrent polysomnographic (PSG) recording in healthy…
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Investigating Hydrophobic Ligand-Receptor Interactions in Parathyroid Hormone Receptor Using Peptide Probes
On the basis of a peptide reported in the literature, referred to here as the Parent Peptide, we conducted systematic SAR analyses to investigate the effects of altering peptide hydrophobicity…
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Designing Bifunctional Nop Receptor-Mu Opioid Receptor Ligands from Nop Receptor-Selective Scaffolds. Part I
We report here our forays into the structure–activity relationships for discovering ‘bifunctional’ NOP–mu opioid receptor (MOP) ligands, starting from our NOP-selective scaffolds.