Publications
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Automated redesign with the general redesign engine
Abstract Given a system design SD, a key task is to optimize this design with respect to minimizing the probability of failures, e.g., catastrophic failures. We consider the task of…
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The Gene Ontology’s Reference Genome Project: a Unified Framework for Functional Annotation Across Species
Here we introduce the Reference Genome project, which brings together those independent efforts into a unified framework based on the evolutionary relationships between genes in these different organisms.
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A Novel Peroxisome Proliferator-Activated Receptor Delta Antagonist, SR13904, has Anti-Proliferative Activity in Human Cancer Cells
The peroxisome proliferator-activated receptor delta (PPARδ) is a ligand-activated, nuclear receptor transcription factor that has a documented role in glucose and lipid homeostasis.
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The Impact of Alcoholism on Sleep Evoked Delta Frequency Responses
The KC incidence and amplitude were negatively impacted in alcoholic men and women with exacerbation of the normal aging effects, particularly over frontal scalp regions.
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Efficient Online Learning and Prediction of Users’ Desktop Actions
We show that simple efficient many-class learning can perform well for action prediction, significantly improving over previously published results and baselines.
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Application of Subsecond Spiral Chemical Shift Imaging to Real-Time Multislice Metabolic Imaging of the Rat in Vivo After Injection of Hyperpolarized 13C1-Pyruvate
We report on the development of an ultrafast, multislice, spiral chemical shift imaging sequence, with subsecond acquisition time, achieved on a clinical MR scanner.
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Backscatter Lidar Observations of Lower Tropospheric Dynamics During Southern California Wildfires
Wavelike features suggesting gravity waves were revealed by lidar observations (from El Segundo, California) of smoke layers produced by large wildfires in the Southern California region during a Santa Ana…
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What We Can Learn About Escherichia Coli Through Application of Gene Ontology
Gene Ontology (GO) is one of the most successful systems for classifying biological function. Although GO is widely used for eukaryotic genomics, it has not yet been widely used for…
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Working and Episodic Memory in HIV Infection, Alcoholism, and Their Comorbidity: Baseline and 1-Year Follow-Up Examinations
Selective memory deficits occur in individuals with human immunodeficiency virus (HIV) infection and those with chronic alcoholism, but the potential compounded effect of these conditions is seldom considered, despite the…
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Zebrafish Chemical Screening Reveals an Inhibitor of Dusp6 That Expands Cardiac Cell Lineages
The dual-specificity phosphatase 6 (Dusp6) functions as a feedback regulator of fibroblast growth factor (FGF) signaling to limit the activity of extracellular signal–regulated kinases (ERKs) 1 and 2.
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Coordinating Asynchronous and Open Distributed Systems Under Semiring-Based Timing Constraints
We focus on coordinating actors and roles through message manipulations based on event-based timing constraints. In addition, different types of timing constraints are generalized into a semiring-based constraint structure; and…
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Calculating Protoplanet Collisions in the Early Solar System
We study shock-synthesized high-pressure phases in meteorites in infer the conditions under which they formed. These phase are found in or adjacent to locally melted veins or pockets that formed…