Biomedical sciences publications
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The Human Epithelial Carcinoma Antigen Recognized By Monoclonal Antibody Ae3 Is Expressed on a Sulfoglycolipid in Addition to Neoplastic Mucins
We have carried out carbohydrate microarray analyses of one of the monoclonal antibodies, AE3, that has been regarded the ‘most carcinoma specific’ in respect to its ability to detect HCA…
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Detection of Inflammatory Arthritis By Using Hyperpolarized 13 C-Pyruvate with Mr Imaging and Spectroscopy
The data presented herein suggest that the presence of inflammation may be detected at 13C-MR spectroscopy as the increased conversion of hyperpolarized 13C-pyruvate into 13C-lactate.
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Genetic Variability of Smoking Persistence in African Americans
We undertook an association analysis by using a genotyping array that includes 2,100 genes to analyze smoking persistence in unrelated African American participants from the Atherosclerosis Risk in Communities study.
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Effect of Fenoterol Stereochemistry on the β2 Adrenergic Receptor System: Ligand-Directed Chiral Recognition
The β2 adrenergic receptor (β2-AR) is a model system for studying the ligand recognition process in G protein-coupled receptors. Fenoterol (FEN) is a β2-AR selective agonist that has two centers of…
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Nicotinic Receptor Agonists Decrease L-Dopa-Induced Dyskinesias Most Effectively in Partially Lesioned Parkinsonian Rats
To further understand how nicotine mediates its antidyskinetic action, we investigated the effect of nicotinic receptor (nAChR) agonists in unilateral 6-OHDA-lesioned rats with varying striatal damage.
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Associations of Cyp2A6 Genotype with Smoking Behaviors in Southern China
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Application of Double Spin Echo Spiral Chemical Shift Imaging to Rapid Metabolic Mapping of Hyperpolarized [1 – 13C]-Pyruvate
This work extends the spCSI sequence by incorporating double spin-echo radiofrequency (RF) pulses to eliminate the need for phase correction and obtain high quality spectra in magnitude mode.
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Systems Level in Silico Pathway Analysis Predicts Metabolites That Are Potential Antimicrobial Targets
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Identification of Antimicrobial Activity Among FDA-Approved Drugs for Combating Mycobacterium Abscessus and Mycobacterium Chelonae
The purpose of this work is to identify new candidate drugs for treating non-tuberculous mycobacteria (NTM) by testing FDA-approved drugs for antimicrobial activity.
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A Platform for the Detection of Trypanosomes Via Selective Small Molecule Recognition
Trypanothione (TSH2), a metabolite unique to trypanosomal parasites, was evaluated as a potential biomarker for trypanosomal infection using fluorescence as the means of detection.
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Phase 0 Clinical Chemoprevention Trial of the Akt Inhibitor Sr13668
We designed and conducted the first-ever phase 0 chemoprevention trial to evaluate and compare the effects of food and formulation on SR13668 bioavailability.
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A Melanoma Molecular Disease Model
This paper describes such a Melanoma Molecular Disease Model reflecting the latest scientific, clinical, and technological advances.