Publications
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(R,S)-Ketamine Metabolites (R,S)-Norketamine and (2S,6S)-Hydroxynorketamine Increase the Mammalian Target of Rapamycin Function
Subanesthetic doses of (R,S)-ketamine are used in the treatment of neuropathic pain and depression.
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The α7 nicotinic receptor agonist ABT-107 decreases L-Dopa-induced dyskinesias in parkinsonian monkeys
Since rodent studies also suggested an involvement of α7 nAChRs in LIDs, we tested the effect of the potent, selective α7 agonist ABT-107 [5-(6-[(3R)-1-azabicyclo[2.2.2]oct-3-yloxy] pyridazin-3-yl)-1H-indole].
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Blockade of α6* nAChR Reduces L-Dopa-Induced Dyskinesias; Studies Using Parkinsonian α6* nAChR Gain-of-Function Mice
To understand the mechanism through which α6β2* nAChRs regulate L-dopa-induced AIMs, we used gain-of-function α6* nAChR (α6L9’S) mice. This mutation results in enhanced sensitivity to nicotine/acetylcholine and prolonged receptor-mediated activity.
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Entity Centric Feature Pooling for Complex Event Detection
In this paper, we propose an entity centric region of interest detection and visual-semantic pooling scheme for complex event detection in YouTube-like videos.
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The α7 nicotinic receptor agonist ABT-107 protects against nigrostriatal damage in rats with unilateral 6-hydroxydopamine lesions.
The finding that smoking is inversely correlated with Parkinson’s disease and that nicotine attenuates nigrostriatal damage in Parkinsonian animals supports the idea that nicotine may be neuroprotective.
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The SRI AVEC-2014 Evaluation System
We explore a diverse set of features based only on spoken audio to understand which features correlate with self-reported depression scores according to the Beck depression rating scale.
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Control Systems Security from the Front Lines
As part of this special issue on control systems for the energy sector, guest editors Sean Peisert and Jonathan Margulies put together a roundtable discussion so readers can learn about…
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Pharmacokinetics and Dose-Range Finding Toxicity of a Novel Anti-HIV Active Integrase Inhibitor
This paper reports on the pharmacokinetics and toxicokinetics of compound 1 and the relevance of these findings with respect to further development of this integrase-targeted antiviral agent.
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Automated Data Integration
HiperFuse automates procedures for extracting, cleaning, restructuring and provisioning data, enabling investigators analyzing the data to spend more of their time focusing on what hypotheses to test, correlations to study,…
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PARC Developments in Biomedical Devices
Advancements towards an electro-chemical biosensor system based on direct, additive printing of biomaterials will be described that enables biomarker measurement via non-invasive continuous operation.
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Network-Layer Trust in Named-Data Networking
This paper explores root causes of, and some cures for, content poisoning attacks in NDN.
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Comparison of conductor and dielectric inks in printed organic complementary transistors
Two types of printable conductor and a bilayer gate dielectric are evaluated for use in all-additive, inkjet-printed complementary OTFTs.