Biomedical sciences publications
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Optogenetic Silencing of Hypocretin/Orexin Neurons Using Transgenic Expression of a Light-Driven Proton Pump
Arch may be better suited for long-term circuit inhibition, and may serve as an important tool for deciphering the role of Hcrt signaling in the maintenance of wakefulness.
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Varenicline Markedly Decreases Antipsychotic-Induced Tardive Dyskinesia in a Rodent Model
Tardive dyskinesia is a potentially irreversible drug-induced movement disorder that arises as a side effect of antipsychotic therapy. Antipsychotics form the mainstay of treatment for schizophrenia and bipolar disorder and,…
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Diffustion Tensor Imaging Detects Callosal Fiber Integrity Change over a 1-Year Follow-up in Chronic Alcoholics Who Maintained Sobriety
Here, we investigated change in CC microstructural fiber integrity over one year in 12 (7w, 5m) alcoholics (ALC) and 13 (7w, 6m) age-matched controls (CTL). ALC and CTL did not…
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Autonomic Regulation across Phases of the Menstrual Cycle and Sleep Stages in Women with Premenstrual Syndrome and Healthy Controls
To investigate the influence of menstrual cycle phase and the presence of severe premenstrual symptoms on cardiac autonomic control during sleep, we performed heart rate variability (HRV) analysis.
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Development of Powder-in-Bottle Formulation of Hydroxyurea with Methylparaben Preservative
The compatibility of hydroxyurea with excipients in closed cap conditions at 30°C/65%RH and 40°C/75%RH storage for up to 6 weeks was also studied.
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A Regression Model for Risk Difference Estimation in Population-Based Case-Control Studies Clarifies Gender Differences in Lung Cancer Risk of Smokers and Never Smokers
Additive risk models are necessary for understanding the joint effects of exposures on individual and population disease risk. Yet technical challenges have limited the consideration of additive risk models in…
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Formulation Development of Acyclovir/Tenofovir Loaded Two-Polymer (SR-2P) Bioadhesive Vaginal Gel
The in vitro release of drugs from the optimized gel formulation in simulated vaginal fluid was characterized using in-line Franz diffusion cell with regenerated cellulose membrane.
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Microinjections of the Hypocretin Antagonist Almorexant Vs. Gabaergic Agonist Zolpidem in Basal Forebrain Show Differential Effects on Cortical Adenosine Levels in Freely-Moving Rats
We used in vivo microdialysis and HPLC analysis to examine cortical adenosine (ADO) levels following BF microinjections of ZOL (0.6 µg/0.2 µl), ALM (1.0 µg/0.2 µl), or VEH (aCSF) combined…
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Neural Correlates of Cognitive Interference and Response Switching in Mild Parkinson Disease
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Imaging Hippocampal Neuronal Activity across Sleep/Wake States in Freely Behaving Mice
We have utilized a combination of methodologies that collectively enable time-lapse imaging of CA1 neuronal calcium dynamics in behaving mice over periods of many weeks.
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Aberrant Heat Shock Protein Response Is Accompanied by Oxidative Injury in Aged DJ-1 Deficient Mice
Loss of DJ-1 function contributes to pathogenesis in Parkinson’s disease. Here, we investigate the impact of aging and DJ-1 deficiency in mice.
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α4β2* and α7 Nicotinic Receptors Play a Role in L-Dopa-Induced Dyskinesias; Studies Using Parkinsonian Knockout Mice
Since α4a5β2 nAChRs are also predominantly on striatal dopamine terminals, these data suggest that drugs targeting α4β2 nAChRs may reduce L-dopa-induced dyskinesias in late stage Parkinson’s disease.