Publications
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The Stereoselective Sulfate Conjugation of 4′-Methoxyfenoterol Stereoisomers by Sulfotransferase Enzymes
The presystemic sulfate conjugation of the stereoisomers of 4′-methoxyfenoterol, (R,R′)-MF, (S,S′)-MF, (R,S′)-MF, and (S,R′)-MF, was investigated using commercially available human intestinal S9 fractions, a mixture of sulfotransferase (SULT) enzymes.
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Adaptive and Discriminative Modeling for Improved Mispronunciation Detection
In this work, we extend our approach with the use of model adaptation and discriminative modeling techniques, inspired on methods that have been effective in the area of speaker identification.
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Trace Amine-Associated Receptor 1 Partial Agonism Reveals Novel Paradigm for Neuropsychiatric Therapeutics
Here we report on the identification and characterization of the first selective and potent TAAR1 partial agonist.
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Effects of audio and ASR quality on cepstral and high-level speaker verification systems
We evaluate the effect that improved audio quality has for speaker verification performance, using a recently released full-bandwidth version of microphone data from the SRE2010 evaluation.
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Salience-Based Compression: Providing FMV Over Low-Bit Rate Channels
We introduce Salience-Based Compression (SBC), a vision-guided pre-filtering technology, coupled with standards-based video coding.
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Adaptive Smoothing in Real-Time Image Stabilization
This paper discusses several novel methods that have demonstrated on a real-time platform including an IIR filter, a single Kalman filter and an interactive multi-model filter.
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Alphaviruses: Population Genetics and Determinants of Emergence
This review discusses the ecology, epidemiology and molecular virology of the alphaviruses, then focuses on three of the most important members of the genus.
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Discovery and Optimization of Benzotriazine Di-N-Oxides Targeting Replicating and Nonreplicating Mycobacterium Tuberculosis
These data along with measurements of the physiochemical properties and pharmacokinetic profile demonstrate that BTOs have the potential to be developed into a new class of antitubercular drugs.
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Magic Mirror: A Virtual Handbag Shopping System
We present an augmented reality system based on Kinect for on-line handbag shopping. The users can virtually try on different handbags on a TV screen at home.
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Comparative Analysis of the Substrate Preferences of Two Post-Proline Cleaving Endopeptidases, Prolyl Oligopeptidase and Fibroblast Activation Protein Alpha
Post-proline cleaving peptidases are promising therapeutic targets for neurodegenerative diseases, psychiatric conditions, metabolic disorders, and many cancers.
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Cortical nNOS Neurons Co-Express the NK1 Receptor and are Depolarized by Substance P in Multiple Mammalian Species
To evaluate the degree of co-expression of nNOS and NK1 in the cortex among mammals, we used double immunofluorescence for nNOS and NK1 and determined the anatomical distribution in mouse,…
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Lead Optimization of Antimalarial Propafenone Analogues
Careful examination of the bioavailability, pharmacokinetics, toxicology, and efficacy of this series of compounds using rodent models revealed orally bioavailable compounds that are nontoxic and suppress parasitemia in vivo.