Publications
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ICOS-Based Chimeric Antigen Receptors Program Bipolar Th17/Th1 Cells
Here we demonstrate that redirection of primary human T cells with a CAR containing the inducible costimulator (ICOS) intracellular domain generates tumor-specific IL-17-producing effector cells that show enhanced persistence.
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Sleep/Wake Regulation and Cortical EEG Are Disturbed in the Neuroligin-3 Rat Model of Autism
This study demonstrates the presence of sleep/wake abnormalities in a model of ASD, consistent with the presence of sleep disruptions found in ASD. The observed decreases in NREM and increased…
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BaySci: A Partnership for Bay Area Science Education—August 2014 Evaluation Report
We examined how and to what degree science instruction changed in the classrooms of districts, schools, and individuals participating in BaySci programming. We sought evidence of changes in classroom practice,…
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Recent Advances in Computer-Aided Drug Design as Applied to Anti-Influenza Drug Discovery
Zanamivir (Relenza™) and oseltamivir (Tamiflu(®)) are two antiviral drugs currently recommended by the CDC for treating influenza. Both are examples of the successful application of structure-based drug design strategies.
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Cyanide Detoxification by Molybdenum Sulfur Complexes
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Role of Conjugate and Local Terminators for Ionospheric Dynamics at Arecibo
Using some recent Plasma drift data at Arecibo, we present evidences of Electric Field (E) changes induced by sunrise and sunset transitions at both local and conjugate regions.
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Characterization of Genetic Variation in the Vgll4 Gene in Anorexia Nervosa
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A Multiparameter Aerosol Classification Method and Its Application to Retrievals from Spaceborne Polarimetry
Classifying observed aerosols into types helps to understand aerosol sources, transformations, effects, and feedback mechanisms; to improve accuracy of satellite retrievals; and to quantify aerosol radiative impacts on climate.
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Cortical nNOS/NK1 Neurons Are Regulated by Cholinergic Inputs
CCh has a network effect on excitability within the cortex, as both presynaptic and postsynaptic effects result in an oscillating pattern of nNOS/NK1 neuron excitability.
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White Matter Microstructural Recovery with Abstinence and Decline with Relapse in Alcohol Dependence Interacts with Normal Ageing: A Controlled Longitudinal DTI Study
Background Alcohol dependence exacts a toll on brain white matter microstructure, which has the potential of repair with prolonged sobriety. Diffusion tensor imaging (DTI) enables in-vivo quantification of tissue constituents…
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Recruiting Participants for Large-Scale Random Assignment Experiments in School Settings
We report here on our experiences in recruiting participants for random assignment experiments in public primary and secondary schools. Our perspective is based on over twenty current and completed randomized…
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Building a Breathprint: Biomarkers of Exposure Due to the Toxicant Trochloroethylene
Our pilot studies indicate that we can detect TCE and other VOCs in the breath environment that are indicative of neuronal degeneration. Pending studies will investigate the relationship between toxicant exposure…