Publications
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NMR Characterization of an Oligonucleotide Model of the MiR-21 Pre-Element
We have used NMR spectroscopy to characterize an oligonucleotide stem loop structure based on the pre-element of an oncogenic microRNA, miR-21.
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Representing Roles in a Biology Textbook
In this paper, we consider the roles in a biology textbook, adapt a definition of roles based on upper ontologies, and relate it to the corresponding notions in linguistics and…
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Spoken Language Recognition Based on Senone Posteriors
This paper explores in depth a recently proposed approach to spoken language recognition based on the estimated posteriors for a set of senones representing the phonetic space of one or…
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Partially Ordered Knowledge Sharing and Fractionated Systems in the Context of Other Models for Distributed Computing
Traditional models based on strong computing primitives, such as atomic transactions, should be replaced by weaker models such as the partially ordered knowledge sharing model, which we motivate in this paper…
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Mining Structure Fragments for Smart Bundle Adjustment
In this work we show that, when using conjugate gradient solvers, there is a computational advantage in “grouping” factors corresponding to sets of points (fragments) that are co-visible by the…
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Strategies towards Compact UV Laser Sources
There is increasing interest in developing compact UV laser sources that emit at wavelengths below 300 nm.
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Building Community & Commitment with a Virtual Coach in Mobile Wellness Programs
Here we present a quantitative analysis from a 2-week field study where we test new FittleBot strategies to increase FittleBots effectiveness in building team community.
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Cortical nNOS/NK1 Neurons Are Regulated by Cholinergic Inputs
CCh has a network effect on excitability within the cortex, as both presynaptic and postsynaptic effects result in an oscillating pattern of nNOS/NK1 neuron excitability.
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White Matter Microstructural Recovery with Abstinence and Decline with Relapse in Alcohol Dependence Interacts with Normal Ageing: A Controlled Longitudinal DTI Study
Background Alcohol dependence exacts a toll on brain white matter microstructure, which has the potential of repair with prolonged sobriety. Diffusion tensor imaging (DTI) enables in-vivo quantification of tissue constituents…
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Recruiting Participants for Large-Scale Random Assignment Experiments in School Settings
We report here on our experiences in recruiting participants for random assignment experiments in public primary and secondary schools. Our perspective is based on over twenty current and completed randomized…
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Building a Breathprint: Biomarkers of Exposure Due to the Toxicant Trochloroethylene
Our pilot studies indicate that we can detect TCE and other VOCs in the breath environment that are indicative of neuronal degeneration. Pending studies will investigate the relationship between toxicant exposure…
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Development of an Agonist of the TGF-Beta Signaling Pathway to Treat Alzheimer’s Disease
Alzheimer’s disease (AD) is a neurodegenerative disorder that leads to progressive cognitive dysfunction. Current knowledge of the processes leading to AD is still limited, and no effective treatments are available.…